Volume 8, Issue 1 (6 2025)
Mod Med Lab J 2025, 8(1): 32-40 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rahmati E, Farzanbakhsh S, Vosough M. Universal Donor: From Serologic Compatibility to Genomic Bioengineering. Mod Med Lab J 2025; 8 (1) :32-40
URL: http://modernmedlab.com/article-1-162-en.html
URL: http://modernmedlab.com/article-1-162-en.html
Abstract: (11 Views)
In this paper, we analyze how the idea of universal donors has developed from the classic serological ABO system through to the novel approaches in genomic bioengineering. First, we discuss the existing paradigm of type O blood being used as universal donors and the drawbacks associated with the use of serological matching, particularly in the context of organ transplantation. Then, using a literature review on the latest advancements, we describe new approaches for making universal donors, such as blood group antigen enzymatic conversion and CRISPR-Cas9 gene editing, which make it possible to produce hypoimmunogenic cells. Main barriers to developing these technologies lie in the balance between T lymphocytes and natural killer (NK) cell immune response, genetic diversity within a population, and implementation of novel bioengineering approaches in a clinical setting.
Keywords: Universal Donor
Type of Study: Review Article |
Subject:
Medical Sciences
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
