en سلول های بنیادی و پزشکی بازساختی Stem Cell and Regenerative Medicine مقاله کوتاه پژوهشی Brief Original Article Up to now, enormous smart materials have been engineered with physical stimulators such as temperature, electric field, magnetic field, light, ultrasound, mechanical stimuli, chemical stimulators such as pH and reduction, or biological stimulators such as antigen glucose and enzyme in regenerative medicine. Smart materials have numerous properties, such as responding to controlled drug release, “ON-OFF” switch activities, prolonged blood circulation, ability to specific triggers, enhanced diagnostic accuracy, increased tumor accumulation, and therapeutic efficacy. In this review, notable research achievements of smart materials responsive to various stimuli involving responsive mechanisms and applications are summarized and discussed separately. Drug delivery, Regenerative medicine, Smart material, Stimuli responsive materials, Tissue engineering 39 51 http://modernmedlab.com/browse.php?a_code=A-10-73-2&slc_lang=en&sid=1 Niloufar Rezaei niloooofar.rz@gmail.com 10031947532846001509 10031947532846001509 No Department of Regenerative Medicine, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Iman Akbarzadeh imanakbarzadeh71@yahoo.com 10031947532846001510 10031947532846001510 No Department of Regenerative Medicine, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Sara Kazemi sarakazemi7613@gmail.com 10031947532846001511 10031947532846001511 No Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 1665659911, Iran Leila Montazeri montazeri.leila@gmail.com 10031947532846001512 10031947532846001512 No Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 1665659911, Iran Ibrahim Zarkesh ibrahimz_edl@yahoo.com 10031947532846001513 10031947532846001513 No Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 1665659911, Iran Nikoo Hossein-Khannazer nikookhannazer@gmail.com 10031947532846001514 10031947532846001514 No Gastroenterology and Liver Diseases Research Center, ResearchInstitute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Moustapha Hassan moustapha.hassan@ki.se 10031947532846001515 10031947532846001515 No Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital-Huddinge, Sweden Massoud Vosough masvos@Royaninstitute.org 10031947532846001516 10031947532846001516 Yes Department of Regenerative Medicine, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran