Modern Medical Laboratory Journal
Mod Med Lab J
Medical Sciences
http://modernmedlab.com
1
admin
2371-770X
2371-770X
10.30699/mmlj17
en
jalali
1399
3
1
gregorian
2020
6
1
3
2
online
1
fulltext
en
نقش تنظیمی MicroRNA های بیان شده دیفرانسیل و ویروسی آنکوپروتئین ها در آنژیوژنز مربوط به ویروس پاپیلومای انسانی سرطان
The Regulatory Role of Differential Expressed MicroRNAs and Viral Oncoproteins in Angiogenesis of Human Papillomavirus-Related Cancer
ایمنی شناسی
Immunology
مقاله مروری
Review Article
According to the performed study, the most important known cause of cervical cancer is contamination with HPV infection which is the main cause known for complex molecular changes leading to the neck epithelial cells, and if the virus is of the high risk type, it leads to cervical cancer. Studies and analysis of performed experiments, have led to the belief that some miRNAs play a key role in cancer prognosis and the evaluation of them can indicate the existence of cervical cancer. Analysis results indicate that in cervical cancer, some oncoproteins such as E5, E6, and E7, begin their activity when the HIV infection starts. Each of these oncoproteins have various functions. They can cause disorders or performance improvements. The present paper provides a brief review of these oncoproteins as well as miRNAs involved in cervical cancer.
Cervical cancer, HPV, E6 and E7, P53, Angiogenesis
88
99
http://modernmedlab.com/browse.php?a_code=A-10-79-4&slc_lang=en&sid=1
Atyieh
Soleymani
jalili.arsalan@yahoo.com
10031947532846001472
10031947532846001472
No
Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Nazli
Alibalazadeh Yamchlou
jalili.arsalan@yahoo.com
10031947532846001473
10031947532846001473
No
Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Arsalan
Jalili
jalili.arsalan@yahoo.com
10031947532846001474
10031947532846001474
Yes
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amin
Ebrahimi Sadrabadi
Amin.ebrahimi@royaninstitute.org
10031947532846001475
10031947532846001475
No
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran