en اثر متقابل ویروس انسانی پاپیلوما ویروس (E6 ،E7) و پروتئین رتینوبلاستوما (pRb) در رگ زایی بیماری های عفونی Infectious Diseases مقاله مروری Review Article Cervical cancer is a type of cancer that occurs in the squamous cells of the uterus. Different types of Human Papilloma Virus (HPV), a sexual infection, play a key role in endometrial cancer. It has double-stranded DNA with a genome composed of 8000 base pairs and it is classified into two types of low risk and high risk, and it seems that two 16 and 18 high-risk strains are responsible for more than 70% of endometrial cancer cases and they only host those human cells which may not be obvious clinically or they may cause benign and malignant lesions. This type of cancer depends on two E6, and E7 oncoproteins that play role in formation of tumor structurally and angiogenesis compared to other important factors that have a significant role in the progression of this type of cancer. The present study aims to investigate the performance of two E6 and E7 oncogenes and their inhibitory activity in line with suppressing P53 and PRB and also investigating the role of angiogenesis in the function of these oncogenes Cervical cancer, HPV, E6 and E7, PRB, Angiogenesis 74 82 http://modernmedlab.com/browse.php?a_code=A-10-79-3&slc_lang=en&sid=1 Nazli balazadeh Yamchlou Nazli Alibalazadeh Yamchlou jalili.arsalan@yahoo.com 10031947532846001467 10031947532846001467 No Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Atyieh Soleymani Atyieh Soleymani jalili.arsalan@yahoo.com 10031947532846001468 10031947532846001468 No Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Arsalan Jalili Arsalan Jalili jalili.arsalan@yahoo.com 10031947532846001469 10031947532846001469 Yes Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Amin Ebrahimi Sadrabadi Amin Ebrahimi Sadrabadi Amin.ebrahimi@royaninstitute.org 10031947532846001470 10031947532846001470 No Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran