en بیوشیمی پزشکی Medical Biochemistry مقاله پژوهشی Original Research Article <div style="text-align: justify;"><span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt">Type 2 Diabetes Mellitus (T2DM) presents a significant global health challenge, affecting metabolic processes and increasing cardiovascular risk. Elevated blood sugar levels in diabetes contribute to heightened clot formation and disrupt coagulation mechanisms, fostering atherosclerosis and altering platelet activity. This study aims to analyze the coagulation markers Prothrombin Time (PT), Partial Thromboplastin Time (PTT), and platelet counts in T2DM patients, investigating the influence of elevated blood sugar levels on coagulation changes. Conducted at the Nepal Cardio Diabetes and Thyroid Centre, this cross-sectional observational study selected T2DM-diagnosed patients as cases and healthy individuals as controls. Blood samples were analyzed using standard techniques, and statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 21. Significant differences were observed in PT, International Normalized Ratio (INR), PTT, and platelet counts between the cases and controls, indicating altered coagulation pathways and reduced platelet counts in T2DM patients. These findings suggest a hypercoagulable state in diabetic patients, contributing to atherogenesis.</span></span></span><br> &nbsp;</div> Prothrombin Time, PTT, INR, Type 2 Diabetes Mellitus, SPSS 7 11 http://modernmedlab.com/browse.php?a_code=A-10-920-1&slc_lang=en&sid=1 Uttam Budhathoki uttambc123@gmail.com 10031947532846002239 10031947532846002239 Yes Nepal Cardio Diabetes and Thyroid Centre, Kathmandu, Nepal Anil Bhattarai anbh10000@yahoo.com 10031947532846002240 10031947532846002240 No Department of Cardiothoracic Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Kathmandu, Nepal Srijana Shrestha sriajanak82@gmail.com 10031947532846002241 10031947532846002241 No Nepal Cardio Diabetes and Thyroid Centre, Kathmandu, Nepal