en هماتولوژی Hematology مقاله گزارش مورد Case report Article <span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt">Background:</span></b><span style="font-size:10.0pt"> Cold agglutinin disease is a rare condition affecting 1 per million population annually. It is usually associated with hemolytic anemia. We report a case of interference of cold agglutinin with red blood cell (RBC) parameters in a non-hemolytic case.</span></span></span><br> <span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt">Case:</span></b><span style="font-size:10.0pt"> A 31-year-old male presented with complaints of a cough and fever. Routine blood investigation revealed normal hemoglobin with low RBC, packed cell volume (PCV), high mean corpuscular volume (MCH), and mean corpuscular hemoglobin concentration (MCHC). The indirect Coombs test was negative. So, interference due to cold agglutinin was suspected, which was confirmed following the disappearance of agglutinin after incubation at 37</span><m:omath><i><span style="font-size:10.0pt"><span cambria="" math="" style="font-family:"><m:r>&deg;</m:r></span></span></i></m:omath><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="position:relative"><span style="top:2.0pt"> </span></span></span></span><span style="font-size:10.0pt">C for 30 minutes.</span></span></span><br> <span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt">Conclusion:</span></b><span style="font-size:10.0pt"> The possibility of RBC cold agglutinin should be suspected if there is any mismatch between RBC parameters and appropriate measures should be taken for proper delivery of results.</span><span style="font-size:10.0pt"></span></span></span><br> <span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"></span></span></span><br> <br> &nbsp; ,complete blood count,cold agglutinin,histograms,RBC Indices 24 28 http://modernmedlab.com/browse.php?a_code=A-10-914-1&slc_lang=en&sid=1 Sailuja Maharjan sailuzaa73@gmail.com 10031947532846002168 10031947532846002168 Yes Department of Pathology, Kulhudhuffushi Regional Hospital, Kulhudhuffushi, Maldives. Chandan Thakur dr.thakur25@yahoo.com 10031947532846002169 10031947532846002169 No Department of Internal Medicine, Vitalcare, Kulhudhuffushi, Maldives. Rabina Tazia rnkt43@gmail.com 10031947532846002170 10031947532846002170 No Department of Gynecology and Obstetrics, Kulhudhuffushi Regional Hospital, Kulhudhuffushi, Maldives. Sumnima Mainali sumnimamainali@gmail.com 10031947532846002171 10031947532846002171 No Department of Gynecology and Obstetrics, Kulhudhuffushi Regional Hospital, Kulhudhuffushi, Maldives