en ایمنی شناسی Immunology مقاله مروری Review Article <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Novel therapeutic options such as adoptive immunotherapy have been progressed drastically for treating hepatocellular carcinoma (HCC). Chimeric antigen receptor T cell (CAR-T) therapy is a kind of adoptive immunotherapy that has been associated with promising results in hematopoietic malignancies. However, its application is associated with some obstacles in solid tumors, including heterogeneity of tumor antigens, immunosuppressive microenvironment, and serious adverse complications. In recent years, some progress has been made in this regard, and several preclinical and phase I clinical trial studies have been conducted concerning the application of CAR T-cells in solid tumors. This study will review the possibilities of CAR T cell therapy in HCC, the most common primary liver cancer associated with high morbidities and mortality globally.</span></span> Hepatocellular Carcinoma, Cancer Immunotherapy, Adoptive Cell Therapy, Chimeric Antigen Receptor (CAR) T-cells 19 27 http://modernmedlab.com/browse.php?a_code=A-10-73-6&slc_lang=en&sid=1 Mohammad Amin Shahrbaf aminshahrbaf41@gmail.com 10031947532846001766 10031947532846001766 Yes Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Kian Goudarzi kiangoudarzi2@gmail.com 10031947532846001767 10031947532846001767 No Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Kimia Karimi Taheri kimia.sbmu@yahoo.com 10031947532846001768 10031947532846001768 No Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hani Keshavarz Alikhani hani.keshavarz865@gmail.com 10031947532846001769 10031947532846001769 No Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Masoumeh Noori m.nouri@rsct.ir 10031947532846001770 10031947532846001770 No Research and Development Department, Royan Stem Cell Technology Co, Tehran, Iran. Faculty of Sciences, University of Science and Culture, Tehran, Iran