Showing 6 results for Tissue Engineering
Ensieh Zahmatkesh, Massoud Vosough,
Volume 2, Issue 1 (1-2019)
Abstract
Pluripotent stem cells (PSCs) may be offered as an unlimited cell source for the hepatocyte generation. The generation of hepatocytes from stem cells in vitro would provide an alternative cell source for applications in drug discovery and cell transplantation. In this review, we discuss different approaches to generate pluripotent stem cell-derived hepatocytes, advantages, limitations for each method and finally, how three-dimensional (3D) strategy can improve the maturation of PSCs -derived hepatocytes.
Bahare Shokoohian, Babak Negahdari, Massoud Vosough,
Volume 2, Issue 2 (6-2019)
Abstract
Regenerative medicine, deals with functional reconstruction of damaged tissues or organs after severe injuries chronic diseases, while body's natural responses are not sufficient. In this field, stem cells due to their exclusive potential in self-renewal and differentiation into other cell types, are the main sources of functional cells in regenerative medicine. However, challenges in stem cell culturing highlighted the need for new methods, which in addition to maintaining cell viability and functionality, can control the precise microarchitecture for cells in a three dimensional structure. In this review we focus on the application of different types of bioprinting technology in regenerative medicine and we overview how this method has been able to make progress in 3D-cell culturing and tissue engineering protocols.
Mehdi Soleymani-Goloujeh, Samaneh Saberi, Faezeh Shekari,
Volume 2, Issue 2 (6-2019)
Abstract
Extracellular vesicles were initially known as cellular waste carriers, while recent studies demonstrate that extracellular vesicles play important biological roles in all aspects of life-from single cells to mammalians. Their pathophysiological roles in some diseases like cancer are being decoded. Extracellular vesicles are divided into some classes and there are different strategies to isolate them. Regenerative medicine is a collective term which comprised of different approaches to heal and repair damaged tissues and organs. A wide spectrum of options in regenerative medicine, makes this more dynamic field, which is appealing prospect for cell therapists and tissue engineers. EVs derived from mesenchymal stem/stromal cells and other probable sources are one of the options on the table to regenerate damaged tissues with lower risks, but their potential roles have not been fully elucidated. This cell-free based approach inspires cell therapist and tissue engineers in order to control immune reactions as well as regeneration at the same time.
Amirhosein Nezakat Yazdi, Nastaran Sahraei, Mehdi Ahmadifar,
Volume 3, Issue 1 (1-2020)
Abstract
Cells that make up the body's tissues are usually three-dimensional architecture, the threedimensional culture system enables cells to create natural and in vivo interactions which is an ideal environment for 3D (Three-dimensional) cell growth and issues such as exchange of similar food exchanges inside Capillary in living tissue. In tissue engineering discussion, cell scaffolding is highly important and is used for tissue implantation, which will eventually dissolve or demolish after applying to the body. Bone formation can occur via two separate pathways, within the cartilaginous and within the membrane. The vascular endothelial growth factor is a key regulator of angiogenesis. The combination of osteoactivity is a major parameter in the engineering structures and the function of the bones and osteoblasts is very important in maintaining and repairing bone in the laboratory conditions. Also, in this study, we investigated transcription factors, epigenetic reforms, miRNAs, and Sox family in tissue engineering. Between transcription factors, TLX's core receiver is essential for maintaining neural stem cells and NCSs reviver. Epigenetic reforms maybe a major factor that links genetic and environmental factors to the risk of osteoporosis. Micro-RNAs regulate bone and chondrogenic differentiation by targeting important transcription factors and relative pathways during skeleton maturation. The members of the Sox family interact in a wide range of cellular tissues and thus create a variety of effects on cellular metabolism.
Niloufar Rezaei, Iman Akbarzadeh, Sara Kazemi, Leila Montazeri, Ibrahim Zarkesh, Nikoo Hossein-Khannazer, Moustapha Hassan, Massoud Vosough,
Volume 4, Issue 1 (1-2021)
Abstract
Up to now, enormous smart materials have been engineered with physical stimulators such as temperature, electric field, magnetic field, light, ultrasound, mechanical stimuli, chemical stimulators such as pH and reduction, or biological stimulators such as antigen glucose and enzyme in regenerative medicine. Smart materials have numerous properties, such as responding to controlled drug release, “ON-OFF” switch activities, prolonged blood circulation, ability to specific triggers, enhanced diagnostic accuracy, increased tumor accumulation, and therapeutic efficacy. In this review, notable research achievements of smart materials responsive to various stimuli involving responsive mechanisms and applications are summarized and discussed separately.
Dr Melika Zanganeh Motlagh, Dr Nikoo Hossein-Khannazer, Dr Nazanin Mahdavi, Dr Pouyan Aminishakib, Dr Massoud Vosough,
Volume 6, Issue 1 (1-2023)
Abstract
Dental pulp stem cells(DPSCs) are a class of stem cells which originate from dental pulp tissue and possess multiple stem cell characteristics including high clonogenicity, differentiation capacity and immunomodulatory effects. DPSCs can be used in different stem cell-based therapy to treat a variety of diseases, such as autoimmune, orthopedic, and neurological diseases.
Recent studies showed that DPSCs combined with biomaterials provides an effective approach to craniofacial bone regeneration and reconstruction of bone defects. Scaffolds improve cell attachment, proliferation, differentiation, and migration. In the present study we discuss different combination of biomaterials with DPSCs.
